Why is it accurate to think of each human being as the owner of a library of ancient information?
How would DNA translocation produce cancer?
In the fruit fly, Drosophila melanogaster, a spineless (no wing bristles) female fly is mated to a male that is claret (dark eyes) and hairless (no thoracic bristles). Phenotypically wild type F1 female progeny were mated to fully homozygous (mutant) males and the following progeny (1000 total) were observed.
Three loci, mitochondrial malate dehydrogenase that forms a and b (MDHa, MDHb), glucouronidase that has forms 1 and 2 (GUS1, GUS2), and a histone gene that has + and - variants(H+, H-), are located on chromosome #7 in humans. Assume that the MDH locus is at position 35, GUS at position 45, and H at position 75. A female whose
Assume that investigators crossed a strain of flies carrying the dominant eye mutation Lobe on the second chromosome with a strain homozygous for the second chromosome recessive mutations smooth abdomen and straw body. The F1 Lobe females were then backcrossed with homozygous smooth abdomen, straw body males and the following p
Assume that the genes for tan body and bare wings are 15 map units apart on chromosome II in Drosophila. Assume also that a tan-bodied, bare-winged female was mated to a wild type male and the resulting F1 phenotypically wild type females were mated to tan-bodied, bare- winged males. Of 1000 offspring, what would be the expe
1. A short-tailed mutant of mouse was discovered. Multiple crosses of this mouse to normal mice produced 27 normal, long-tailed mice and 25 short-tailed mice. A series of crosses among short tailed mice were made and 21 short-tailed mice and 11 long-tailed mice were produced. Determine which phenotype is dominant and explain
1. G6PD is an enzyme found in human white blood cells. It is made by a gene that has 2 alleles, A and B. In females, cells either make the A type or the B type, but never both. This is very different from most other enzymes, where all cells in a heterozygote make both types of enzyme. What is the most reasonable explanation f
1. Two black guinea pigs were mated repeatedly over several years. They produced 29 black progeny and 9 white progeny. Explain these results, giving the genotypes of parents and progeny. 2. In horses, black is dependent on a dominant gene (B) and chestnut upon its recessive allele (b). The trotting gait is due to a dominan
In fruit flies, the phenotype for eye color is determined by a certain locus. E indicates the dominant allele and e indicates the recessive allele. The cross between a male wild type fruit fly and a female white-eyed fruit fly produced the following offspring. Wild-type Wild-type White-eyed White-eyed Brown-eyed male f
How does one's food pattern over time contribute to the development of diseases? What do you think is the interplay between genetics and eating habits? How early should one be concerned with preventing diseases? Infancy?
Using the table below, build a genetic distance matrix which gives the total number of genetic differences between pairs of unique haplotypes in the sample. The first box is filled in for you, by way of an example. Haplotypes 1 2 3 4 5 1 -- 2 2 -- 3 -- 4 -- 5
If Curly wings are recessive to normal wings and Barred Eyes is recessive to normal eyes, cross Curly Barred to a normal normal fly. What would be the expected ratios if they were linked or unlinked? If you had 2,500 flies, how many would you expect to see?
In a particular species of guppy, tails can either be long or short and either feathered or straight. A cross between a true-breeding long, feather-tailed male guppy and a true-breeding short, straight-tailed female guppy produces progeny that all have short, straight tails. a) express the genotypes of the adults in the cr
1. In ladybugs, wings with 4 spots are recessive to those with 2. Assume 11% of the ladybugs have 4 spot wings. If the mutation rate of 2 spot to 4 spot alleles is 0.047, what percentage of the next generation will be heterozygous? 2. You look at two populations of moose, one from Canada, and one from Newfoundland, an islan
3. In plants, flower color is controlled by incomplete dominance, where red and blue are the two homozygous conditions and purple indicates heterozygous. An initial population contains 14 red, 70 purple, and 24 blue individuals. Give exact allele and expected genotype frequencies for this population. Now assume that the heter
All living organisms contain genetic information that provides several functions inherent to the individual organism and the perpetuation of its species. a) Describe how genetic material contributes to the regulation of physiological function and development b) Discuss how the nature of genetic material both perpetuates
Genetics Problem Set. See attached file for full problem description.
In humans, brown eyes (B) are dominant over blue (b)*. A brown-eyed man marries a blue-eyed woman and they have three children, two of whom are brown-eyed and one of whom is blue-eyed. Draw the Punnett square that illustrates this marriage. What is the man's genotype? What are the genotypes of the children? (* Ac
There is a gene R on the long arm of the same chromosome as the huntington gene. (1) Draw a labelled diagram to show the chromatids of a diploid cell at the end of anaphase 1 of meiosis, for a person who is heterozygous for both characters. (2) Draw a labelled diagram to show the product cells derived from this cell at tel
How would a pair of sister chromosomes differ from homologous chromosomes? If the reproductive cell only has 23 chromosomes, then how come all of our body cells (somatic cells) have 46 chromosomes? Briefly describe the constituent molecules found within a chromosome. You may use a diagram to illustrate your answer. Refer
Part I: Imagine you have a friend who is getting married and plans on starting a family right away. She asks your advice about preconception genetic screening because she is concerned about the chance that her future children could have cystic fibrosis. Her fiancé has a sister that has cystic fibrosis, and she has a cousin wh
1) Consider a genetic locus that could hold either of the alleles P or p (where P is dominant, p is recessive). Consider a second genetic locus (for some other unrelated trait) that could hold either of the alleles R or r. Listed below are some genotypes of individuals for each of these loci: a) PPRR b) PpRR
2. The inbred mouse strains BALB/c and C57BL have different Ig heavy chain allotypes: The BALB/c allele is IgHa, whereas the C57BL allele is IgHb. C57BL mice make good immune responses to the antigen "Z", but BALB/c mice respond poorly. Assume you produced (BALB/c X C57Bl)F1 mice, then back-crossed these F1s to BALB/c. You te
Recall that allelic forms of Ig constant regions exist. In the mouse, the locus encoding Ig heavy chain constant regions is named IgH. The inbred mouse strains BALB/c and C57BL/6 have different IgH alleles: BALB/c mice are IgHa and C57BL/6 mice are IgHb. They also differ in their humoral response to phosphorylcholine (PC). While
Herbie is a typical American college freshman who loves to eat. His second most favorite food is hotdogs. He cuts them into his Kraft macaroni and cheese at a 1:1 ratio, going through a score of hotdogs each week. He doesn't know his brand is preserved with sodium nitrite, but his stomach is slowly finding out as it's acid conve
In pings, coat color may be sandy, red, or white. A geneticist spent several years mating true-breeding pigs of all different color combinations, even going so far as to obtain true-breeding lines from different parts of the country. For crosses 1 and 4 below, she encountered a major problem: her computer crashed and she lost
A. What is your evidence that DNA is the genetic molecule of heredity? b. The Human Genome Project began with two goals: to know the sequence of genes on all the human chromosomes and to know the sequence of bases on all the human chromosomes. With this, individuals with genetic defects could have proper treatment. Pre
1. What are the three types of RNA? What is the function of each? 2. Define mitosis and cytokinesis. What would a daughter cell look like if cytokinesis did not occur after mitosis? 3. Define the following terms: gene, allele, dominant, recessive, true breeding, homozygous, heterozygous, cross-fertilization, self-fertiliza
Describe two positive potentialities of the human genome project, and one negative possibility.