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DNA translocation and cancer

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How would DNA translocation produce cancer?

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The most notable example of a DNA translocation occurs in the Philadelphia translocation that leads to Chronic Myelogenous Leukemia (CML). In this ...

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Short paragraph with web references examining an example of DNA translocation that produce cancer.

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Leukemia and the Philadelphia Chromosome

Please help with the following problem. Provide at least 300 words in the solution.

Those with chronic myelogenous leukemia have a piece of chromosome 9 connected to chromosome 22 in the cancerous cells. This connection in chromosomes in referred to as a 9:22 translocation, and is called the Philadelphia chromosome. Please explain how this chromosome translocation could generate genetic changes that result in cancer?

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