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DNA Replication and Bacterial Infections

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Ciprofloxacin, erythromycin, and acyclovir are used to treat microbial infections. Ciprofloxacin inhibits DNA gyrase. Erythromycin binds in front of the A site on the 50S subunit of a ribosome. Acyclovir is a guanine analog.

What steps in protein synthesis are inhibited by each drug?
Which drug is more effective against bacteria? Why?
Which drug is more effective against viruses? Why?
Which drugs will have effects on the host's cells? Why?
Use the index to identify the disease for which acyclovir is used. Why is it more effective than erythromycin for treating this disease?

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DNA Replication and Bacterial Infections

Ciprofloxacin, erythromycin, and acyclovir are used to treat microbial infections. Ciprofloxacin inhibits DNA gyrase. Erythromycin binds in front of the A site on the 50S subunit of a ribosome. Acyclovir is a guanine analog.

What steps in protein synthesis are inhibited by each drug?
Ciprofloxacin- it inhibits bacterial nuclear DNA synthesis, so that bacteria rapidly die. The target is the enzyme DNA gyrase (topoisomerase II), which is responsible for the supercoiling and uncoiling of the DNA. Supercoiling of the DNA allows the long DNA molecule to fit into the cell. Uncoiling of the structure is the initiative step for replication, transcription and repair of the DNA. Thus, prolonged inhibition will eventually lead to the death of the cell.

Erythromycin - Erythromycin, an antibiotic that inhibits the synthesis of vital proteins in susceptible bacteria, may be either bacteriostatic (i.e., ...

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Concept map of antimicrobials

Draw a concept map using the words in the list below. Then write a paragraph summarizing your map - it should be clear from your summary that you understand the meaning and significance of each term on the list, and where it fits into the overall concept.

(Your diagram may take any form - flow chart, circle diagram with a central theme and others radiating out from it, etc - as long as it shows how the terms relate to each other and to the main idea. The only unacceptable format is a list of definitions)

Word List:

Antimicrobials
Antibiotics
Cell wall
Protein synthesis
DNA Replication & Transcription
Vancomycin
Penicillin G
Erythromycin
Tetracycline
Ciprofloxacin
Rifampin
Amphotericin B
Beta-lactamase
Broad spectrum
Narrow spectrum
Fungi
Amantadine
Chloroquine

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