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Leukemia and the Philadelphia Chromosome

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Please help with the following problem. Provide at least 300 words in the solution.

Those with chronic myelogenous leukemia have a piece of chromosome 9 connected to chromosome 22 in the cancerous cells. This connection in chromosomes in referred to as a 9:22 translocation, and is called the Philadelphia chromosome. Please explain how this chromosome translocation could generate genetic changes that result in cancer?

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Solution Summary

This solution helps with a problem regarding DNA repair and cancer. The explanation is given in 307 words.

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Problem: Those with chronic myelogenous leukemia have a piece of chromosome 9 connected to chromosome 22 in the cancerous cells. This connection in chromosomes in referred to as a 9:22 translocation, and is called the Philadelphia chromosome. Please explain how this chromosome translocation could generate genetic changes that result in cancer?

Solution:
The Philadelphia chromosome refers specifically to a translocation of genetic material between a particular section of chromosome 9 with ...

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