Purchase Solution

SNP linkage

Not what you're looking for?

Ask Custom Question

You are trying to map a human gene thought to be involved in cat allergies. Because
you know this gene is on chromosome 20, you decide to examine the linkage of
several SNPs located on chromosome 20 with respect to the gene involved in cat
allergies. You have obtained DNA from 10 individuals and know whether they
are allergic to cats. Your SNP results are shown in the table below.
SNP tests for chromosome 20. (+ = presence of SNP)
allergic to
cats?
SNP1 SNP2 SNP3 SNP4 SNP5
yes - + + + -
no - + - - +
no - - - - +
yes + + + - -
yes + - + + +
yes - - + + -
no + + - - +
yes + + + + -
yes - - + + +
no + - - - -
A. Which SNP is most likely to be tightly linked to the gene involved in cat
allergies? Explain your answer.

B. Of the SNPs tested above, which is likely to be the next closest to the gene
responsible for the allergic state? Why?

Purchase this Solution
Solution Preview

In order to answer these questions, we need to determine whether any of the SNPs are ALWAYS associated with allergies.

Let's take a look at the data:

SNP1 SNP2 SNP3 SNP4 SNP5
yes - + + + -
no - + - - +
no - - - - +
yes + + + - -
yes + - + + +
yes - - + + -
no + + - - ...

Purchase this Solution
Free BrainMass Quizzes
Biochemistry Basics

A refresher quiz to test your knowledge of basics concepts of biochemistry.

Light and Sight Vocabulary

This quiz introduces basic definitions of vocabulary related to light and how human eyes. This information is important for an understanding of sight.

Hemophilia: Fact or Fiction

Do you know the truth about hemophilia? Test your knowledge here.

Basic Immunology Quiz

Intro to immuno quiz. Covers the basics of immunology and recognition of foreign substances by the body.

Identifying Variables in Science Experiments, Part 2

Using sample experiments, test yourself to see if you can identify independent, dependent, and controlled variables. Identifying variables is key in understanding and developing experiments. The questions are biology related, but this can be applied to any area of science.

View More Free Quizzes
Related BrainMass Solutions

  • Multifactorial Traits and Genetic Disorders

    A single snp in the MET gene causes an increase risk for autism. A microsatellite in the disrupted DISC gene is associated with autism. A SNP and haplotype HEP3 is associated with Asperger's syndrome.

  • DNA Sequence Variation, Epigenetics, and Gel Electrophoresis

    The most common of these (and probably the answer this question is looking for) is the polymorphism, also known as the single nucleotide polymorphism (SNP) or single nucleotide variation (SNV). There are several possible consequences of a SNP.

  • RFLPs, VNTR, SNP - definitions and use

    SNP stands for single nucleotide polymorphisms. In both non-coding and coding regions DNA there are single nucleotides in a particular location that vary between individuals.

  • genome project

    Find the single nucleotide polymorphisms (SNP) within this gene. 5. Design PCR primers for an exon of the gene using a primer design program. Response attached. The solution examines the genome project.

  • Genetics: Observed Frequencies

    Is variation at this SNP consistent with the expectations of Hardy-Weinberg equilibrium? Why or why not? According to the Hardy-Weinberg equilibrium, the sum of the frequencies of the three genotypes should equal 1.

  • A Dendrogram Using Single Linkage and Hierarchical Procedures

    Treating the sample correlations as similarity measures, cluster the stocks using the single linkage and complete linkage hierarchical procedures. Draw the dendrogram and compare the results.

  • Applying a Decision-Making Framework

    The stakeholders are the management including CEO Anne, the employees of Linkage Construction, the shareholders of Linkage Construction, the banks that have lent to Linkage Construction and may lend to Linkage Construction and the government The ethical

  • Case Management and Effective Linkage

    360378 Case Management and Effective Linkage What is one possible barrier to an effective linkage?

  • Momsaccharides/products, linkage, benedict's, acetal etc

    The carbon and these oxygens are in an acetal linkage. Upon hydrolysis with the appropriate enzyme, what will be the products? Give the ring structures Describe the linkage between the two monosaccharides (ie alpha (1-6).

View More Related Solutions