A transformation experiment is performed with a donor strain that is resistant to four drugs: A, B, C, D. The recipient is sensitive to all four drugs. The treated recipient-cell population is divided up and plated on media containing various combinations of the drugs. The results are shown in the table below. Drug # co
You have created 3 independent mouse strains carrying the same transgene by non-targeted transgenesis. All 3 strains have otherwise identical genetic backgrounds, yet all 3 have different phenotypes. What are potential explanations for this phenotypic variability?
A single base-pair mutation in the gene of a model organism has been found. However, an individual homozygous for this mutation shows no phenotype. How is this possible?
EDIT to the problem below: I just realized that the various numbers of offspring add up to 9900, not 10,000, which is the supposed total. So for problem #2, I randomly added 100 to my recombinant numbers and got the answer, 30.1, which turned out to be correct. But the same thing did not work for problem #1. Adding 100 to the
Hi. Can you help me with the following genetics problem, please: "Consider a pair of homologous chromosomes heterozygous for three genes (e.g., ABC/abc) during prophase I of meiosis. Let the sister chromatids of one homolog be numbered 1 and 2 (ABC); and the sister chromatids of the other homolog be numbered 3 and 4 (abc).
Your sister has cystic fibrosis and you are contemplating having children of your own. Your mate recalls having a cousin with the disease. What is the risk that one or more of your children will have cystic fibrosis? If you can draw a pedigree of your family, assuming you have only one sister and your mate has only one sister.
Outlines of types of epistasis are included.
"a" is a dominant mutant allele of the A gene, and "b" is the recessive mutant allele of the B gene. To see the mutant phenotype, one requires either an "a" mutant phenotype or a "b" mutant phenotype (both mutations are not necessary). What would the F2 segregation ratio be (wild type to mutant) of the cross of an aabb mutant
You cross an aa bb mutant plant with an AA BB wild type. What would the F2 segregation ratio be (wild type to mutant) if: a.) both mutations, a and b, were recessive? b.) both mutations were dominant? c.) one mutation was dominant and one recessive? (assume both mutations are required for the mutant phenotype) (assume t
Background The Hardy-Weinberg law states two things: 1. If no outside forces are acting on the population, then the allele frequency will remain constant from one generation to the next. 2. If no outside forces are acting on the population, then the genotype frequencies will be p^2, 2pq, and q^2. The converses of these sta
If the somatic cells of a human male were found to contain one Barr body in their nucleus the most likely chromosome makeup of the individual would be: XO XX XYX XXY XXX
A chromosome has eight alleles in the order ABCDEFGH. Which of the following represents an inversion? ABBCDEFGH ABEDCTFG ABCDGH ABCDEEFFGH ABCDFGH
Which of the following statements is true? The Hardy-Weinberg equation provides a way to: Predict the response to a solution for a quantitative tract Determine the degree of drift affecting a population Calculate test credibility Predict genotype frequencies of given alleles Predict episodes of proverbial equilib
Of the genes that code for CAK, wee1, and cdc25, which would you expect, when mutated, to stop a cell from continuing to divide? Which would you expect, when mutated, to cause the cell to proliferate in an uncontrolled manner?
Suppose you are given the task of genetically modifying a mouse so that its skin cells secrete a bitter tasting protein that will protect it from predation. What factors would you have to consider in order to achieve this goal? You only need to consider protein targeting, do not be concerned with how you would get the gene int
Assume that a trait is determined by a single pair of genes where one allele is dominant and the other is recessive. In a population, 30% of the females are pure dominant, 60% are hybrid, and 10% are pure recessive. If a pure recessive male mates with a random female and their first offspring has the dominant trait, what is th
Using the NCBI website resources find information related to BRCA genes, related to human breast cancers. Use "locus link" at http://www.ncbi.nlm.nih.gov/ (Tutorials are available if you get stuck) 1) find the chromosomal position of the BRCA-1 gene 2) what is another gene located next to BRCA-1 at this chromosome 3
If a child more strongly resembles one parent's physical traits than the other parent's, the explantion could be due to chromosome movements during? A. anaphase II B. metaphase II C. prophase II D. anaphase I E. telophase I This study is discussed.
What fraction of the time will the cross of Aa Bb Cc with Aa Bb Cc produce an offspring of genotype aa bb cc? A. 1/64 B. 1/32 C. 3/64 D. 1/16 E. 9/64
In cocker spaniels, black coat color (B) is dominant over red (b), and solid color (S) is dominant over spotted (s). If two dihybrids (Bb Ss) were crossed, which would be produced? A. black and spotted pure-breeding forms B. black and solid pure-breeding forms C. red and solid pure-breeding forms D. red and spotted pu
A. parents B. genotype C. phenotypes D. alleles E. genes
A. be homozygous. B. display the same phenotype as the RR parent. C. display the same phenotype as the rr parent. D. have the same genotype as the RR parent. E. have the same genotype as the rr parent.
An individual with a genetic makeup of aaBB is said to be what?
What are some of the methods that scientists have used to study the components, processes, and outcomes of cell division?
1 Two new hair dyes A and B were tested in the Ames test. Both were tested with and without liver homogenate. Two auxotrophic strains of bacteria were used, one in which the auxotrophy was caused by a nonsense mutation (mutant 1) and the other by a frameshift mutation (mutant 2). After treatment the cells were plated on minimal
What is the definition of the "isoelectric point" (pI) of a protein?
4. In yeast, wild type colonies are white. Adenine-requiring auxotrophs (ad) are red when grown on medium containing limiting amounts of adenine. This is due to the accumulation of a red precursor in adenine biosynthesis. If cells from an ad strain are plated on minimal medium most cells don't produce colonies but two rare ty
(a) Give the genotypes of the two parental goats, showing gene arrangement and gene order. (b) Give the % recombination between each pair of genes. (c) Draw a map showing the positions of all genes and distances between genes, where appropriate (d) Give the formula and calculate the coefficient of coincidence (e) Calcula
An autosomal dominant disease (Huntington disease) is being transmitted in the pedigree below. A two-allele marker (designated 1 and 2) has been typed for each family member. What are the mother's haplotypes i.e. which alleles are inherited together? What is the recombination frequency for the marker and the disease locus? What
Five single rII deletion mutants of phage T4 were spot-tested in all pairwise combinations to test for their ability to give r+ recombinants. The results are given in Table (a). Five different point mutations were then tested in the same way for their ability to recombine with the five deletions. These results are given in Table