Potential problems with transgenic mouse strains.
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You have created 3 independent mouse strains carrying the same transgene by non-targeted transgenesis. All 3 strains have otherwise identical genetic backgrounds, yet all 3 have different phenotypes. What are potential explanations for this phenotypic variability?
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Solution Summary
The potential problems with transgenic mouse strains are examined. The phenotypic variability are given.
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1. The transgene may have been mutated at some point in the process.
2. The transgene ...
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