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    Potential problems with transgenic mouse strains.

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    You have created 3 independent mouse strains carrying the same transgene by non-targeted transgenesis. All 3 strains have otherwise identical genetic backgrounds, yet all 3 have different phenotypes. What are potential explanations for this phenotypic variability?

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    1. The transgene may have been mutated at some point in the process.

    2. The transgene ...

    Solution Summary

    The potential problems with transgenic mouse strains are examined. The phenotypic variability are given.