Explain the purpose (and briefly the method) of generating a TCR transgenic mouse ? Why TCR transgenic mice are often made on a rag-/- background ?© BrainMass Inc. brainmass.com October 9, 2019, 5:14 pm ad1c9bdddf
The purpose of generating a TCR transgenic mouse is to generate a mouse with a population of T-cells sharing a single TCR specificity. This is done by cloning the desired already-rearranged TCR genes (TCR is composed of 2 peptides encoded by 2 distinct genes). Mice expressing these cloned TCR ...
The generation of diversity purposes are determined. The expert explains the purpose of generating a TCR transgenic mouse.