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Genetics

Multi-Sequence Alignment

Given the following alignments of three sequences, what is the sum-of-pairs score? Assume that the scoring system: match score = 1, mismatch score = -2, gap score = -4. ACCTGTGAC AC -TGTAAC ACCTGT- AC

Hypothesis Testing

Given that Ho = null hypothesis and Ha= alternative hypothesis then consider the following situations. 1. You are a juror in a murder trial. State the null and alternative hypothesis and explain why. What are two mistakes that can occur here (the two mismatches between what reality is and what the decision is). 2.

Find sequence similarity between two 100 Mb DNA sequences.

Q1) Determine where and how similar two 100 Mb DNA sequences are. Assume that similarity will vary over the lengths of the sequences. 1.Restate the biological problem in computational terms. 2.What kinds of data do you need? 3.What controls do you need? 4.Do you need to define the problem's conditions more precisely?

Dihybrid crosses: Using the principles of Mendelian genetics, determine the genotypes and phenotypes of the resulting offspring from a parental dihybrid cross. The solution demonstrates how to find the phenotypic and genotypic ratios of the resulting progeny.

A scientist studying diploid pea plants is interested in two particular traits of the plant: pea color and pea texture. From previous studies, the scientist knows these traits to be genetically unlinked; therefore, these traits follow the Mendelian principles of segregation and independent assortment. The scientist also knows th

Complete the genome of this particular organism.

Given the complete sequence of an organismâ??s genome, 500 Mb, find motives that might regulate genes, based on the putative motivesâ?? proximity to known expressed genes. These motives are likely to occur relatively infrequently (ca. 1 motif/50 Kb). Use the flow chart which I'm attaching because will help you, now answer

Crossing pure-bred plants

Each plant was crossed with normal (leafy) pure-bred plants to generate the following phenotypic ratios: F1 phenotype F2 phenotype Line 1 x leafy all leaves 3:1 leaves/no leaves Line

Genetic Problems

Solve all of these problems using a Punnett Square. If you cannot reproduce the square using software, then you may do them by hand and scan in the image of your solution and submit all images in the one document. In the eastern collared lizard, Crotaphytus collaris, commonly known as Mountain Boomers, the genes for length of

Punnett Square Applied to Dihybrid Problems

Solve all of these problems using a Punnett Square. If you cannot reproduce the square using software, then you may do them by hand and scan in the image of your solution and submit all images in the one document. In certain bacteria, an oval shape (A) is dominant over round (a) and thick cell walls (B) are dominant over thin

Monohybrid Problems

Solve all of these problems using a Punnett Square. If you cannot reproduce the square using software, then you may do them by hand and scan in the image of your solution and submit all images in the one document. In summer squash, white fruit color (W) is dominant over yellow fruit color (w). If a squash plant homozygous for

Gene frequency is explicated.

One-thousand individuals were screened for their genotype at the MN blood group locus. The numbers of each genotype were: MM MN NN 298 489 213 Assuming random mating, calculate the gene frequency for the M allele and the expected genotype frequencies. Use the chi-squared test to determine that mating is r

yeast and human genes

You have found a yeast gene that appears to encode a DNA polymerase, and you hypothesize that a related gene exists in humans. Describe, in detail, the experiments you would use to test this hypothesis.

Mutation Rate, Frequency, and Lifespan

Could you please help me with an assignment by discussing the following topic: Compare and contrast mutation rate and mutation frequency. Describe the implications for organisms that have long life spans (e.g., humans) and short life spans (e.g., mice). Spontaneous mutation rates in humans are generally higher than in E. coli

Genetic code mutations are examined.

An experimenter is studying a gene that codes for a very small polypeptide phe-his-gly-cys-gly. He treated the cells with different mutagens with the following results to the protein: â?¢ Normal: phe-his-gly-cys-gly â?¢ Treatment #1: phe-his-gly-cys â?¢ Treatment #2: ser-his-gly-cys-gly â?¢ Treatment #3: phe-his-arg-

This solution provides a map of a typical Ti-based plasmid from agrobacterium tumefaciens, explains the various elements present and why they are needed to transfect a gene into plant cells.

Early research established that the full naturally occurring Bt protoxin is a protein containing 1156 amino acids (later work has shown that insecticidal activity results from a much shorter amino acid sequence). The Bt protoxin gene was introduced into plant cells using a vector based on the Ti plasmid of Agrobacterium tume

Transcription in eukaryotes

Compared to prokaryotes, the eukaryotic genome is more complex and contains large amounts of noncoding sequences. Describe the process by which eukaryotic promoters are recognized. How does the transcriptional machinery find the appropriate promoters in the complex eukaryotic nucleus?

Hox genes conservation among species

For many of the mammalian Hox genes, it has been possible to determine that some of them are more similar to one of the insect HOM-C genes than to the others. Describe an experimental approach using the tools of molecular biology that would allow such a determination.

Mendelian Genetics: Testcross/Punnett Square

A red kerneled wheat plant is crossed with a white-kerneled plant, yielding an F1 plant with all red kernels. A self-cross yields a 15:1 red:white ratio. A test cross yields a 3:1 red:white ratio. Explain the results. Draw Punnett squares for both the self- and test-cross.

Highlight genetically modified organisms.

Compose a letter to a member of Congress representing pro/cons concerning the development and usage of GMOâ??s. (genetically modified organisms(. 3pros 3cons -Thanks

How to analyze data from a reporter assay

** Please see the attached file for the complete problem description ** Information: If Egr-1 is a transcription factor that regulates expression of the GalK gene, then it would be expected that the GalK gene would possess upstream promoter regions to which Egr-1 would bind. Analysis of the published sequence of the GalK g

Demonstrate homologous human chromosomes.

5) Two homologous human chromosomes have the following structure: - -A - - B - - . C - - D - - E - -F - -G - -H - - I - -J - - - -A - - D - -C - . - B - -E - -F - - G - -J - -I - -H - - Where the letters represent genetic markers and the black dot represents the centromere. 1) Diagram the two chromosomes as they would be

Media-Selective and Differential Traits

Explain how one media can identify both the selective and differential nature of the organism. Each one identifies different properties of the organism growing on the agar.

Learning and Genetics

Analyze the relationship between genetics and learning. Thank you so much for your help!

Debate Over Genetic Food Modification

A brief overview of the debate surrounding genetic food modification, the process by which transgenic organisms are created. How is this process similar to the more traditional selective breeding and how is it different? What are the potential benefits of genetic modification of food? What are the concerns of those opposed to

Genetics: mutation and punnet square problems

6) Mutational changes were introduced in a single codon in the gene of T4 phage. The following amino acid substitutions were observed. By following the base changes in the codons determine the codon for each mutant. Assume each amino acid substitution resulted from a single base substitution. Codons for several amino acids are p

Sample Genetics Problems in inheritance

1. A child wonders if she is adopted and hence compares her blood type to those of her parents. Her father is type AB and her mother is type O. What blood type of the child would indicate that she might have been adopted? 2. Color blindness is a sex linked recessive trait in humans. The only member of Judy's family who is

Problems with a Single Chromosome

1) The genes GHI are on a single chromosome in the following order: ---G--------H-------------------------------------- I ------------------ 5 mu 15 mu The distance between G and H is 5 mu and the distance between genes H an I is 15 mu. What are the numbers of various progeny (assume a total of 4