Explore BrainMass

Explore BrainMass


    The term ‘Bioinformatics’ was created by Paulien Hogeweg in the 1970s1, to describe the work with biological systems. Bioinformatics is the use of technology to further understand biological structures, primarily DNA base sequence - it encompasses the data collection, storing, processing, and analyzing or mining of data. It is an interdisciplinary field as it utilizes biology, computer science, math, chemistry and biological engineering.

    There are two types of sequencing Bioinformatics looks at: static and dynamic. Static sequences are not continually changing, and thus permutations of nucleic acids other biological structures are analyzed for interactions and overlying patterns. Dynamic sequences are ones that are under constant changes or are in changing internal conditions, examples are sequencing work on ligands. 

    Well-known contributions from Bioinformatics is the ‘Human Genome Project’2 – which is an ongoing research project that aims to map out and process the whole human base sequence. Once the data is interpreted the data can show patterns in the DNA sequence that correlates to a multitude of diseases, conditions, and can give insight on the production of treatments. Examples of diseases that are being screened are breast cancer and Alzheimer’s.



    1. Hogeweg, P. (2011). The Roots in Theoretical Biology. PLoS Computational Biology, 7(3).  

    2. About The Institute. National Human Genome Research Institute. Retrieved at http://www.genome.gov/27534788

    © BrainMass Inc. brainmass.com April 17, 2024, 1:45 am ad1c9bdddf

    BrainMass Solutions Available for Instant Download

    Erythrocyte Sedimentation Rate (ESR) Questions

    See the attached file. 1. What is the purpose of the ESR assay? 2. State the normal range for ESR in (state reporting units) Men? Women? 3. State the specimen requirement for ESR and time limits for performing the test. 4. What is the required time for performing a sed rate or ESR? 5. List the 4 sources of technical errors

    Genetics: Exons, Sequencing, and Bioinformatics

    Multiple Choice Practice Problems 1) Exon prediction procedures (EX: hexmar frequency) works best in predicting which of the following exons? (A) 3' exons (B) 5' exons (C) Internal coding exons (D) Internal non-coding exons 2) Which of the following scoring matrices would work best for searching for divergent sequence

    Computational biochemistry (bioinformatics)

    I am reviewing for a course in computational biochemistry (bioinformatics) and I have prepared a set of problems to help prepare me for this course. I would like assistance with this problem set, to make sure that I have fully reviewed the necessary information. Five sources are provided throughout.

    Human DNA

    Crimes and DNA In an incident where a man rapes a woman and get away without being identified, police ask local men to submit a DNA sample (by of which is then placed in the Nat'l Database). Most men in the town voluntarily submit a sample, and none of them matched the sample collected at the crime scene, but a partial match w

    Bioinformatics sequence analysis problem

    Calculate the dynamic programming matrix and an optimal alignment for the DNA sequences GAATTC and GATTA, scoring +2 for a match, and -1 for a mismatch, and with a linear gap penalty of d = 2. Please contact me if you need any more information. The textbook that we are using: "Biological sequence analysis: Probabilistic model