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Acid Base Neutralization

An Acid-Base Neutralization is a reaction where an acid and base react to form a salt. When considering the Arrhenius definition of acids and bases, a neutralization reaction should also produce water in addition to the salt.

Consider the following reaction:

HA + BOH --> AB + H2O

HA is the acid
BOH is the base
AB is the salt
H2O is the water produced by the neutralization reaction

The net ionic equation for the above reaction can be written as follows:

H+ + OH- --> H2O

Although many people think that neutralizations result in a pH of 7 (which is indicated by the color green using a universal indicator), this is not the case as it depends very much on the respective strength of the acid and the base. Consider the neutralization pH of the following pairs:

Strong acid – Strong base: pH = 7
Strong acid – Weak base: pH < 7
Weak acid – Strong base: pH > 7
Weak acid – Weak base: pH = 7

Thus, understanding neutralization reactions is an extremely important component for grasping the concept of acid-base reactions.

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Acetic acid is a good choice to make buffers that are moderately acidic because it is easy to use, inexpensive, and the ions do not interact strongly with most biomolecules. The pKa of acetic acid is 4.75. We want to prepare 1.5 L of buffer at pH = 5.25 that is approximately 50 mM in concentration. You have the following solu

Finding Formula Based on Neutralization Reaction

Salicylic acid, used in the manufacture of aspirin, contains only the elements carbon, hydrogen and oxygen. Each molecule of the acid contains only one acidic hydrogen. When 1.00g of salicylic acid undergoes complete combustion, 2.23g CO2 and 0.39 g of H2O are formed. When 1.00g of salicylic acid is titrated with 0.100M NaOH, 72