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Experiment testing the role of MHC in graft rejection

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Using various inbred strains of mice, design an experiment to determine the importance of the three classes of MHC antigens in graft rejection. Include results and interpretation of the results in your answer.

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This solution gives experimental details explaining how you would test the role of the three different classes of MHC antigens in graft rejection.

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These experiments would use congenic mice, where the mice have been bred such that they differ in select MHC loci but are on the same genetic background. Mice would be obtained on the C57BL/6 background, which is normally of the H-2b haplotype. Congenic mice on this background would have the H-2d ...

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