Purchase Solution

Strategies for Prolonging Graft Survival

Not what you're looking for?

Ask Custom Question

How do each of the following prolong graft survival?
a. antibody to CD4
b. blockade of the interaction between B7 and CD28
c. total lymphoid irradiation

Purchase this Solution
Solution Summary

This solution explains the reasons why certain commonly used strategies for immune suppression are effective at prolonging graft survival. The strategies concerned are: (1) antibodies to CD4, (2) blockade of B7/CD28 interactions, and (3) total lymphoid irradiation.

Solution Preview

CD4 T cells recognize MHC class II molecules, which are not expressed on the majority of the cells in the graft, but are expressed on any professional antigen presenting cells, such as dendritic cells and macrophages, that are present in the grafted tissue. Some of the host CD4 T cells will recognize the donor MHC class II as 'foreign' and become activated. In addition, host antigen presenting cells will take up proteins released from ...

Purchase this Solution
Free BrainMass Quizzes
Light and Sight Vocabulary

This quiz introduces basic definitions of vocabulary related to light and how human eyes. This information is important for an understanding of sight.

Feeding Babies

Do you know the science behind feeding babies? Test your knowledge with this quiz.

How Well Do You Know Your Body?

This quiz will assess the different systems of the human body. It will examine everything from the organs to the cellular processes that occur.

Understanding the Musculoskeletal system

Introduce and understand basic information how the skeletal system and muscular system work in close concert with one another. And how their interaction between muscle and bone, as they work together to allow us movement.

Breastfeeding Basics

How much do you know about breastfeeding? Find out with this quiz!

View More Free Quizzes
Related BrainMass Solutions

  • Tackling Police Corruption in the 21st century

    Officers engaged in graft should receive disciplinary action the first time and immediate dismissal for any other actions of graft.

  • Experiment testing the role of MHC in graft rejection

    The expected results are as follows: Graft onto C57BL/6 mice - graft accepted. Graft onto Balb/C mice - graft rejected. Graft onto congenic mice at MHC class I loci - graft rejected.

  • Role of T Cells in Gaft Rejection

    This solution details how to demonstrate experimentally that T cells are critical for graft rejection. It also addresses whether there is any role for the complement system in graft rejection.

  • Debate the pros and cons of prolonging life.

    435381 Debate the pros and cons of prolonging life. Articulate the pros and cons of prolonging life. The pros of prolonging life is the ability to gain more knowledge and experience more of life.

  • Graft Versus Host Disease in twins

    Please find attached file for the answers. Thanks and cheers! PROBLEM: Graft Versus Host Disease in twins Does Graft Versus Host Disease ever occur between identical twins? If so, what is the reasoning?

  • PICO question

    In addition, carers should receive the proper instructions and strategies to provide successful monitoring for patient progress without being overprotective.

  • Sensitization of the host to antigens from a transplant

    Some dead cells from the graft will be taken up by the recipient's antigen presenting cells, and migrate to the local lymph node.

  • Q4 need concise answers

    Each kind of graft was done on ten mice. *(See Attached) ? From the first table, what do you conclude about the scid mutation? ? From the second table, what do you conclude about the mechanism of graft rejection?

  • Discussion of Police Corruption in the U.S.A

    This is a huge issue and most African Americans such as myself, can attest to being accosted by police for "Driving While Black". Other forms of police corruption including graft are also widespread.

View More Related Solutions