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Role of T Cells in Gaft Rejection

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Describe an experiment that would demonstrate whether T cells are involved in graft rejection.

[Separate question] What role does complement play in graft rejection?

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Solution Summary

This solution details how to demonstrate experimentally that T cells are critical for graft rejection. It also addresses whether there is any role for the complement system in graft rejection.

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To demonstrate that T cells are involved in graft rejection, experiments would be performed in mice that lack T cells to determine if they are still capable of rejecting grafts from another strain of mouse. Normally a skin graft from a white mouse will be rejected by a black mouse, and vice versa. However if the recipient mouse is a strain that lacks T ...

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