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role of T helper cell balance in autoimmune diseases

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Describe the role of T helper cell balance in autoimmune diseases. How is autoimmunity affected by the TCR repertoire?

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The role of T helper cell balance in autoimmune diseases is shown.

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T cells play a major role in autoimmunity. The memory T cells provide a defense against pathogens; some autoreactive T cells exist, but they are quiescent. These "ignorant" T cells do not recognize the antigens for which they are specific (also called "cryptic antigens"). An immune response is initiated against pathogens after the presentation ...

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