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switching from Th1 to Th2 responses

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This solutions describes circumstances where it may be desirable to convert a patients' CD4 T cell response from a Th1-dominated to a Th2-dominated response or vice versa. The solution describes, using examples, diseases associated with these responses, and why each type of immune response may be damaging to the host.

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Solution Summary

This solution describes conditions under which it would be favorable to switch a patient's immune response from a Th1 to a Th2-dominated response. It describes typical Th1 and Th2-driven diseases, and the reasons why these types of responses cause damage to the host are determined.

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Th1 T cell responses are problematic in the setting of autoimmune disease, where T cells attack normal body proteins and cause damage to healthy tissue. Much of the damage caused by these cells is the result of the production of Th1 cytokines, such as gamma interferon, that can act directly and also indirectly via activation of macrophages. Skewing of the T cell response away from a Th1 towards a Th2 ...

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