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    Sensitization of the host to antigens from a transplant

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    Describe the three major theories that may explain how transplant antigens sensitize the transplant recipient.

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    1) MHC class I molecules from any of the cells of the graft can be recognized directly by CD8 T cells from the recipient, as there is a high frequency of cells that can bind to foreign MHC.

    2) Professional antigen presenting cells from the donor express MHC class II and migrate to the recipient's lymph nodes, and ...

    Solution Summary

    This solution deals with a problem in immune recognition after transplantation. The immune system of the recipient is sensitized to antigens from the transplanted tissue, and this solution explains three mechanisms how this can occur.