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    Blood groups - ABO and rhesus

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    What is the ABO and rhesus blood group systems? Why is blood that is not correctly matched destroyed if transfused into a mismatched donor?

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    Solution Preview

    The dominant blood group is the ABO system, that is present on the membrane of red blood cells. The A or B genes encode glycosyl transferases which each add different carbohydrate groups onto H substance on the cell surface. Individuals with both A and B genes (AB blood group) with have both glycosylation patterns, whereas those lacking these genes (O blood group) will have neither. Antibodies against ...

    Solution Summary

    This solution details the basis for the ABO and rhesus blood grouping systems and explains why blood transfusions must be matched for blood group antigens.