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4. An investigator performed cytofluorimetric (FACS) analyses of a mouse strain called C.B20 and a spontaneously arising point mutant that arose in the same strain called "C.B20 scid." Splenocytes from each strain were stained with anti-IgM (green) and anti-CD3 (red), then analyzed. The proportion of cells falling into each phenotypic category defined by these markers were then assessed.
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The table below shows the results from all possible donor-recipient combinations of skin grafts between C.B20, C.B20 scid and another, genetically disparate strain called C57BL. Each kind of graft was done on ten mice.
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? From the first table, what do you conclude about the scid mutation?
? From the second table, what do you conclude about the mechanism of graft rejection?
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1) From the first table, what do you conclude about the scid mutation?
First off, based on the data, you need to know that IgM is from B cells and CD3 is from T cells. The data in table one says that normal mice have few immature immune cells (immature cells wouldn't have IgM or CD3, so they would be IgM-CD3-). They have many more B ...
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