4. An investigator performed cytofluorimetric (FACS) analyses of a mouse strain called C.B20 and a spontaneously arising point mutant that arose in the same strain called "C.B20 scid." Splenocytes from each strain were stained with anti-IgM (green) and anti-CD3 (red), then analyzed. The proportion of cells falling into each phenotypic category defined by these markers were then assessed.
The table below shows the results from all possible donor-recipient combinations of skin grafts between C.B20, C.B20 scid and another, genetically disparate strain called C57BL. Each kind of graft was done on ten mice.
? From the first table, what do you conclude about the scid mutation?
? From the second table, what do you conclude about the mechanism of graft rejection?
1) From the first table, what do you conclude about the scid mutation?
First off, based on the data, you need to know that IgM is from B cells and CD3 is from T cells. The data in table one says that normal mice have few immature immune cells (immature cells wouldn't have IgM or CD3, so they would be IgM-CD3-). They have many more B ...