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    Comparing Myeloid Lineage Deficiencies

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    Choose two of the following myeloid lineage deficiency diseases and describe their similarities and differences.

    Chronic Granulomatous Disease
    Leukocyte Adhesion Deficiency

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    Solution Preview

    Chediak-Higashi Syndrome
    Symptoms of Chediak-Higashi Syndrome repeated and persistent infections that eventually become life-threatening, oculocutaneous albinism (reduced pigmentation of the skin, hair, and eyes), impaired clotting, and neurological defects. This disease is characterized by white blood cells with giant granules. While mildly affected individuals survive into adulthood viral infection can precipitate an accelerated phase in children that leads to hepatosplenomegaly (enlarged liver and spleen), lymphadenopathy (enlarged lymph nodes), and pancytopenia (reduced white blood cells, red blood cells, and platelets) culminating in organ failure. This disease is caused by mutations in the LYST (lysosomal trafficking regulator) that, as the name implies, regulates the trafficking proteins to the lysosome. This organelle is responsible for digesting cellular debris, toxins, bacteria, and ...

    Solution Summary

    Symptoms and causes of Chediak-Higashi, Chronic Granulomatous Disease, and Leukocyte Adhesion Deficiency with web references.