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Polypeptide Chain Structure & Function

In the following polypeptide chain where do you expect to see bends, twists, and
disulfide linkages forming?
Which ones of these amino acids is/are likely to be in the interior of a protein?
Mark the amino acids likely to contribute to the overall charge of the peptide in neutral pH.

Chain:
Ile-Ala-His-Thr-Tyr-Gly-Pro-Phe-Glu-Ala-Ala-Met-Cys-Lys-Trp-Glu-Ala-Gln-Pro-Asp-Gly-Met-Glu-Cys-Ala-Phe-His-Arg

Solution Preview

Bends and twists usually take place at "small, uncharged" amino acids, such as glycine (Gly) and proline (Pro).

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Ile-Ala-His-Thr-Tyr-Gly-Pro-Phe-Glu-Ala-Ala-Met-Cys-Lys-Trp-Glu-Ala-Gln-Pro-Asp-Gly-Met-Glu-Cys-Ala-Phe-His-Arg

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Disulfide links occur at cysteine residues. Therefore, the two cysteine ...

Solution Summary

Solution goes through the chain to mark where bends and twists will be as well as identifying which amino acids may be inside a protein.

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