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Forms of the IL-2 receptor and regulation of T cells.

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This solution describes the several forms of the IL-2 receptor complex, and how the different chains are utilized by IL-2 and other cytokines. It describes the signals provided by each of these receptors to the T cell, and the effects that this has on the T cell.

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This solution describes the various different forms of the IL-2 receptor and the different functions they have in regulating the T cell response.

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The IL-2 receptor consists of three subunits, some of which are shared with other cytokines. The gamma subunit, referred to as the common gamma chain, is used in the receptors for several other cytokines including IL-15, IL-4, IL-6 and IL-7, which are termed the common gamma chain cytokines. The beta subunit is more specific, used by both IL-2 an IL-15. Naive T cells express the gamma and beta chains, which forms a complex with a low affinity for IL-2 and IL-15. Upon T cell activation, the alpha chain of the IL-2 receptor is ...

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