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Signal Transduction-3

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This figure is from Bose et al. 2006 [see attached[ (A) What can be concluded with respect to the regulation of PLCy1, STAT1, DOK1, o-Cat, AXL and FYB by the Her2 receptor. (B) In general, what is the mechanism that regulates how proteins interact with the Her2 receptor? (C) What is different about how the signal for PLCy1 phosphorylation was generated compared to that for DOK1 phosphorylation?

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Her2 is a receptor tyrosine kinase belonging to the EGF receptor (EGFR)/ErbB family. ( 1) Her2 activates and recruits many signaling proteins, including phospholipase C y1(PLCy1), phosphatidylinositol 3-kinases (PI3K), Shc-Grb2-SOS, RasGAP, and Stat(signal transducer and activator of transcription) (1) The autophosphorlation sites in the C-terminal tail of Her2 is responsible for the recruitment events.(1) EGFR signaling pathways have showed that a highly complex signaling network is regulated by Her2 to mediate cell proliferation and transformation (1)

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A) The conclusion with respect to the regulation of PLCgamma1 is that the PLCy1 phosphorylation was inhibited by high concentration of PD168393. Stat1 is also phosphorylated by 3T3-Her 2 cells, and the phosphorylation is inhibited by the PD168393. Dok1 and δ-Catenin are phosphorylated in 3T3-Her2 cells and inhibited by PD168393. Axl is also phoshphorylated in 3T3-Her2 cells and inhibited by ...

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