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Ras/MAPK Signal Cascade After EGFR Activation

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Contained is a description of the signaling cascade that results from EGF stimulation of the Ras-MAPK pathway in cells. A paragraph description is included that tells in relative detail the various steps, and then a brief numbered list of events is given for quick reference in order to improve understanding of this complicated pathway.

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Included it a step-by-step rundown of the canonical MAPK kinase signaling pathway that results from EGFR activation.

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The Ras-MAPK pathway can be triggered by many distinct pathways, including activation of various receptor tyrosine kinases, as well as via mutation of proteins, especially Ras itself. The epidermal growth factor receptor (EGFR) is a very common receptor tyrosine kinase that initiates this pathway. Upon activation of this receptor by its ligands (which include EGF, epiregulin, epigen, and several others), it dimerizes with another EGFR and autophosphorylates on several tyrosine residues.

The phosphotyrosine residues act as docking sites for a multitude of proteins thanks to the inclusion of SH2 (phosphotyrosine-binding) ...

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