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    Signaling defects in immunodeficiency conditions

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    This solution describes the cell interaction and signaling defects in:
    a. SCID
    b. XLA and
    c. XHM

    The solution details how these signaling defects relate to the immunosuppression see in these conditions, and the differences between these diseases.

    © BrainMass Inc. brainmass.com October 9, 2019, 11:52 pm ad1c9bdddf
    https://brainmass.com/biology/cell-signalling/signaling-defects-immunodeficiency-conditions-270500

    Solution Preview

    SCID is caused by a defect in the common gamma chain of cytokine receptors. This forms an essential part of the receptor for several key cytokines such as IL-2, IL-7, IL-15 and IL-6, so individuals with this mutation cannot respond to these critical cytokines. As cytokines in this family are essential for the development of a variety of immune cells, these patients lack T cells, B cells and NK cells and consequently are severely immunodeficient.

    Patients with ...

    Solution Summary

    This solution describes the defects that lead to severe immunodeficiency in several congenital conditions, namely SCID, XLA and XHM.

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