Haplotype Determination using Clark's Algorithm
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Given the SNP genotyping information about the following individual:
Individual 1: Aa Bb CC Dd
Individual 2: aa bb CC DD
Individual 3: Aa Bb CC DD
Individual 4: aa Bb CC dd
Individual 5: aa Bb CC Dd
Use the Clark's algorithm to resolve the haplotypes for each individual. E.g. Individual 1 = (text field aBCd) + (text field AbCD)
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Solution Summary
This solution shows step by step how to determine the haplotypes for each individual. This solution is provided in a clear and concise manner.
Solution Preview
Clark's algorithm begins by finding all homozygotes and single-site heterozygotes
and resolving the resulting known haplotypes.
Homozygotes
Individual 2: (abCD) + (abCD)
Single-site Heterozygotes
Individual 4: (aBCd) + (abCd)
Then, for each known haplotype, look at all the remaining unresolved sequences
and ask whether the known haplotype can be made from some combination of ...
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