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    Haplotype Determination using Clark's Algorithm

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    Given the SNP genotyping information about the following individual:

    Individual 1: Aa Bb CC Dd
    Individual 2: aa bb CC DD
    Individual 3: Aa Bb CC DD
    Individual 4: aa Bb CC dd
    Individual 5: aa Bb CC Dd

    Use the Clark's algorithm to resolve the haplotypes for each individual. E.g. Individual 1 = (text field aBCd) + (text field AbCD)

    © BrainMass Inc. brainmass.com October 9, 2019, 7:07 pm ad1c9bdddf
    https://brainmass.com/biology/dna-chromosomes-and-genomes/haplotype-determination-using-clark-s-algorithm-108455

    Solution Preview

    Clark's algorithm begins by finding all homozygotes and single-site heterozygotes
    and resolving the resulting known haplotypes.

    Homozygotes

    Individual 2: (abCD) + (abCD)

    Single-site Heterozygotes

    Individual 4: (aBCd) + (abCd)

    Then, for each known haplotype, look at all the remaining unresolved sequences
    and ask whether the known haplotype can be made from some combination of ...

    Solution Summary

    This solution shows step by step how to determine the haplotypes for each individual. This solution is provided in a clear and concise manner.

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