H-Y antigen is a sex-specific cell surface antigen produced by the sex-determining gene of the Y chromosome (SRY). H-Y antigen is protein found only in males. TDF (testis determining factor) stimulates production of H-Y antigen.
Both H-Y antigen and TDF genes are on sex determining region of Y chromosome. H-Y antigen stimulates testes development--testes secrete hormones. In absence of H-Y antigen signal, undifferentiated gonad develops into ovary.
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