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    Human Biology: MHC

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    A) Explain what are the differences between H2-Kk and H2-Dd?

    b) How can you predict if a given protein breakdown product (peptide) can be presented by HLA-A2? Please give an example.

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    https://brainmass.com/biology/human-biology/human-biology-mhc-54596

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    Please find the attached solution.

    MHC
    --------------------------------------------------------------------------------
    Hello, this is a two part question. This is for an immunology class for graduate school.

    a) Explain what are the differences between H2-Kk and H2-Dd?

    Differences between H2-Kk and H2-Dd:

    H2-Kk H2-Dd

    i) Cellular localization is plasma membrane i) Cellular localization is Type I membrane
    protein

    ii) MHC Class I molecules play a central role ii) MHC Class I H2 Dd is involved in the
    in the immune system by presenting peptides presentation of foreign antigens to the
    derived from the endoplasmic reticulum immune system
    lumen

    iii) Alternate names for MHC Class I H2 Kk iii) Alternative names for MHC Class I
    antibody [ab25030] are H2k antibody or H2-Ddantibody [ab25057] are
    MHC I antibody.
    a) H2D cell surface glycoprotein

    b) H2 DC1 beta transplantation antigen

    protein antibody
    c) MHC class I H 2Dp antibody
    d) MHC class I H2 antigen antibody
    e) MHC class I heavy chain maturation
    peptide H 2D (d) antibody
    f) MHC H2 D p alpha chain antibody
    g) MICA antibody

    h) Q5k protein antibody
    iv) Specificity: ab25030 reacts with ...

    Solution Summary

    The solution discusses MHC in human biology with lots of detail.

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