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Autoimmunity and Tolerance

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In a multiple-choice quiz the question was: The lack of an immune response to self is called:

A. Autoimmunity
B. Tolerance

The answer was B. Can you explain why tolerance is the best answer? Thanks.

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Solution Summary

This solution explains the difference between autoimmunity and tolerance, and further delineates why tolerance is referred to the lack of an immune response to self.

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The lack of an immune response to self is called:

A.
B. Tolerance

The correct answer is B.

This is tricky, but it is a matter of definition. Tolerance is the lack of an immune response to self. MHC molecules (gene products from MHC genes) control the body's ability to recognize self and non-self. When T cells mature in the thymus, they are checked for their reactivity ...

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