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Autoimmunity and Tolerance

In a multiple-choice quiz the question was: The lack of an immune response to self is called:

A. Autoimmunity
B. Tolerance

The answer was B. Can you explain why tolerance is the best answer? Thanks.

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The lack of an immune response to self is called:

A.
B. Tolerance

The correct answer is B.

This is tricky, but it is a matter of definition. Tolerance is the lack of an immune response to self. MHC molecules (gene products from MHC genes) control the body's ability to recognize self and non-self. When T cells mature in the thymus, they are checked for their reactivity ...

Solution Summary

This solution explains the difference between autoimmunity and tolerance, and further delineates why tolerance is referred to the lack of an immune response to self.

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