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Methotrexate, a potent cancer chemotherapeutic agent

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Methotrexate, a potent cancer chemotherapeutic agent, is a strong competitive inhibitor of dihydrofolate reductase. Describe why this compound is an effective inhibitor of the de novo synthesis of both purine and thymidine nucleotides.

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A short description why Methotrexate is a potent cancer chemotherapeutic agent is provided.

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Methotrexate can act as a cancer inhibitor as it shuts down the ability of the actively dividing cancer cells to synthesize new DNA. It inhibits new DNA synthesis, by directly inhibiting the synthesis of new nucleotides that could be incorporate into DNA. To prevent the synthesis of nucleotides methotrexate inhibits the action dihydrofolate ...

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