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    High levels of alcohol consumption and vitamin B6 deficiency

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    How does high level alcohol consumption cause vitamin B6 (pyridoxal-5-phosphate) deficiency?

    © BrainMass Inc. brainmass.com April 3, 2020, 1:58 pm ad1c9bdddf
    https://brainmass.com/biology/biological-chemistry/alcohol-consumption-vitamin-b6-deficiency-18381

    Solution Preview

    Excellent question!

    There are a few interesting papers you will be able to access online which address this question quite well.

    (1) J Clin Invest. 1975 May; 55 (5): 1026-1032, "Vitamin B6 metabolism in chronic alcohol abuse The effect of ethanol oxidation on hepatic pyridoxal 5'-phosphate metabolism." by R L Vech, L Lumeng, and T K Li

    This article may be found at http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=301849.

    They studied the phenomenon in rat, chronically feeding ethanol to rats for 6 weeks. Essentially, the same results were seen in perfused ...

    Solution Summary

    The real cause of B6 deficiency is not alcohol per se, but the production of acetaldehyde which results from ethanol's oxidation in the liver by ADH. 325 Words.

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