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High levels of alcohol consumption and vitamin B6 deficiency

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How does high level alcohol consumption cause vitamin B6 (pyridoxal-5-phosphate) deficiency?

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Solution Summary

The real cause of B6 deficiency is not alcohol per se, but the production of acetaldehyde which results from ethanol's oxidation in the liver by ADH. 325 Words.

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Excellent question!

There are a few interesting papers you will be able to access online which address this question quite well.

(1) J Clin Invest. 1975 May; 55 (5): 1026-1032, "Vitamin B6 metabolism in chronic alcohol abuse The effect of ethanol oxidation on hepatic pyridoxal 5'-phosphate metabolism." by R L Vech, L Lumeng, and T K Li

This article may be found at http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=301849.

They studied the phenomenon in rat, chronically feeding ethanol to rats for 6 weeks. Essentially, the same results were seen in perfused ...

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