Explaining reactivity of amines with carboxylic acids versus esters
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The question is why there is a distinction between OH and OR as leaving groups. The document also has a question about why a sp3 intermediate is unstable. It is attached in the files below.
© BrainMass Inc. brainmass.com December 16, 2022, 10:54 am ad1c9bdddfhttps://brainmass.com/chemistry/organic-reaction-intermediates-and-mechanisms/explaining-reactivity-of-amines-with-carboxylic-acids-versus-esters-582473
Solution Summary
A brief explanation is given to explain why carboxylic acids don't undergo nucleophilic addition with amines but esters do.
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