Acid Derivatives and Amide Properties
Not what you're looking for?
I need some help in answering these questions. Full explanations please!
1. The correct order of reactivity of acid derivatives towards nucleophilic attack is:
esters > acid anhydrides > amides
amides > esters > anhydrides
carboxylates > esters > amides
anhydrides > esters > amides
2. N-methylacetamide is an example of:
a primary amine
a secondary amide
a tertiary amide
an N,N- disubstituted amide
3. Acids can be reduced to aldehyde by:
treatment with LiAlH4
conversion to acid chloride followed by treatment with LiAlH[OC(CH3)]3
conversion to amide followed by treatment with NaBH4
conversion to ester followed by treatment with LiAlH4
4. Amides are less basic than amines because:
the carbonyl group donates electrons by resonance
the carbonyl group withdraws electrons by resonance
the nitrogen does not have a lone pair of electrons
the nitrogen carries a full positive charge
Purchase this Solution
Solution Summary
This in-depth solution contains full explanations on the bonding and structure of the aforementioned molecules to determine reactivities, structure classification, reduction mechanisms and basicity.
Solution Preview
Question 1
Tutorial Help: In order to answer this, we must understand the nature of an electrophile, that which gets attacked by a nucleophile. The more positive charge around the electrophile, the greater it will be attacked by a nucleophile. Amides, RCONHR, are highly stable structures. Like esters (RCOOR), they can be hydrolyzed in acidic or basic solution. On the other hand, acid anhydrides (RCOOOCR) are very reactive to nucleophiles. Remember, good leaving groups is what makes for a strong ...
Purchase this Solution
Free BrainMass Quizzes
General Chemistry - Classification of Matter
This test will assess your knowledge on the classification of matter which includes elements, compounds and mixtures.
Match Elements with their Symbols
Elements are provided: choose the matching one- or two-letter symbol for each element.
Organic Chemistry Naming: Alkanes
This is a quiz which is designed to assist students with learning the nomenclature used to identify organic compounds. This quiz focuses on the organic compounds called Alkanes.
Functional groups in Organic Chemistry
You will be tested on the names of functional groups in Organic Chemistry. It is very important to know the functional groups to understand Organic reactions.