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    Live vs. cadeveric donors - tissue engineering

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    Organ transplant

    1. Liver and lung lobes and kidneys can be transplanted via live donor. Find an article that describes the differences between live donor and cadaveric organ transplantation. Post a brief summary of the advantages and disadvantages of live vs. cadaveric transplants?

    2. What is your position on organ transplantation?

    3. Does the ability to do live donor transplantation affect your position?

    4. How might tissue engineering affect organ transplantation? Find an article that supports your position.

    2-3 sentences each

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    Solution Preview

    Below I have explained in details about transplantation from live vs. cadaveric donors, the various advantages & disadvantages. Please go through the references mentioned. Take out the portions relevant for your need. I have attached the following:
    # MS Word document
    # PDF of the following articles:
    1. Koo, D. D., Welsh, K. I., Mclaren, A. J., Roake, J. A., Morris, P. J., & Fuggle, S. V. (1999). Cadaver versus living donor kidneys: impact of donor factors on antigen induction before transplantation. Kidney international, 56(4), 1551-1559.
    2. Yoshito Ikada, J. R. Soc. Interface: 2006 3 589-601; DOI: 10.1098/rsif.2006.0124. Published 22 October 2006

    The primary function of a kidney is formation of urine by filtering out the useless components and retaining the important ones. Diseased kidneys of an individual reach a stage known as end-stage renal disease (ESRD) when the kidneys stop functioning. Treatments for kidney failure are hemodialysis, a mechanical process to clean the blood of waste products; peritoneal dialysis, in which toxins are removed by passing chemical solutions through the abdomen; and kidney transplant.
    None of these options is a cure for kidney failure. But a transplant offers the best prospects, given that the transplanted kidney functions successfully.

    Living Donors:
    Kidneys for transplant come from a living donor or a deceased (cadaver) donor. The live donor's remaining kidney enlarges to accommodate the loss of the other kidney. There is a chance of post-operative complication as with any other types of surgery but in general live kidney donors have the same life expectancy, general health and kidney function as others.
    Kidney donation can be successfully done by any living person in good health condition. Hospitals normally give lot of information to about the transplantation process to the donor and he/she needs to sign a consent form before proceeding with the procedure. Few things that need to kept in mind before transplantation and during and after transplantation:
    • To make certain that the cost of living donor surgery, hospitalization, diagnostic tests and evaluation are covered by the insurance.
    • Travel and living expenses are not covered by the insurance.
    • The live donor will usually undergo an evaluation.
    • Tests will be performed to ensure that the donor and recipient are compatible.
    • In some families, several people are compatible donors. In other families, none are suitable.
    • The operation usually takes three hours. Most patients undergoing laparoscopic surgery for kidney donation require a hospital stay of only two to three days.
    • After discharge from the hospital, the donor is seen for follow-up care in the transplant clinic.
    • Donors who undergo laparoscopic surgery often return to work within three to four weeks after the procedure.

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    Solution Summary

    The material above highlights the advantages and disadvantages of organ donation from live and deceased donors. It cites various articles supporting the above. The material also briefly explains the advantage of tissue engineering over traditional organ donation.