A particular DNA mutation produces a UGA stop codon in the middle of the RNA coding for a specific protein. A second mutation in the cell causes a single nucleotide change in a tRNA that enables the correct translation of the protein - meaning, the second mutation suppresses the defect caused by the first. What nucleotide change has most likely occurred in the mutant tRNA molecule and what consequences would the presence of the mutant tRNA have for the translation of the normal genes in this cell?© BrainMass Inc. brainmass.com March 5, 2021, 12:24 am ad1c9bdddf
Stop codons only work because there is no tRNA with an anti-codon for the stop codons' sequences. In this case, the stop codon UGA does not have a corresponding ACT anticodon on a tRNA.
Therefore, the easiest explanation is that a tRNA underwent a single nucleotide mutation to acquire the ACT anti-codon. It's difficult to say what specific nucleotide has most likely been mutated, as it could have gotten an ACT ...
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