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Molecular Biology - Multiple Choice

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1. Which of the following is an accurate statement concerning the differences between DNA and RNA?

a. RNA is usually double-stranded, but DNA is usually single-stranded.
b. RNA has the sugar deoxyribose, but DNA has the sugar ribose.
c. RNA contains three different nucleotides, but DNA contains four different nucleotides.
d. RNA lacks the base thymine (which is found in DNA) and has uracil instead.

2. The DNA sequence of a codon in a gene was changed from AAT to AAC. This type of mutation is called a(n) __________.
a. point mutation
b. insertion mutation
c. deletion mutation

3. The cells in your skin have a different shape and different function from the cells in your liver because the two types of cells have different __________.

a. DNA
b. proteins
c. lipids
d. carbohydrates

4. Genetic recombination (crossing over) produces __________.

a. new chromosomes
b. mutations
c. new combinations of alleles
d. longer chromosomes

5. Which one of the following statements is true?
a. An allele is either dominant or recessive, not in between.
b. A particular gene can have only two alleles.
c. A single trait can be affected by many different genes.
d. The environment is irrelevant to gene expression.

6. What is the root cause of sickle-cell anemia?

a. mutations in the gene that directs the synthesis of the hemoglobin protein
b. an amino acid substitution in the hemoglobin protein
c. malaria
d. abnormally shaped red blood cells

7. What are restriction enzymes?

a. enzymes that are limited (i.e., restricted) in how big they can become
b. vitamins such as vitamin A
c. plasmids
d. enzymes that cleave through a DNA helix wherever they encounter a specific sequence of nucleotides

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1. Which of the following is an accurate statement concerning the differences between DNA and RNA? - d. RNA lacks the base thymine (which is found in DNA) and has uracil instead.

2. The DNA sequence of a codon in a gene was changed from ...

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Molecular biology questions and answers.

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Cell Biology Multiple Choice questions

1. Protein insertion into the mammalian ER membrane is typically
a. cotranslational c. pretranslational
b. post-translational d. quasitranslational

2. In N-glycosylation of proteins in the ER lumen, sugar(s) are added to the nascent chain at once.
a. 1 c. 7
b. 3 d. 14

3. All of the following proteins interact with exposed amino acids during protein folding in the ER except:
a. BiP c. PDI (protein disulfide isomerase)
b. calnexin and calreticulin d. prolylisomerase

4. Type I membrane proteins have all of the following properties except:
a. cleavable signal sequence c. internal stop-transfer sequence
b. internal signal-anchor sequence d. N-out, C-in topology

5. Proteins that do not fold properly in the ER lumen are degraded in the cytosol by
a. the etiosome c. the proteasome
b. the microsome d. the ribosome

6. Sorting of protein to mitochondrian and chloroplasts is
a. cotranslational c. pretranslational
b. post-translational d. quasitranslational

7. Tom/Tim and Toc/Tic protein complexes are involved in
a. post-receptor recognition events in the cytosolic folding of proteins prior to import into mitochondria or chloroplasts
b. pre-proteasomal steps in tagging aged proteins for degradation
c. protein translocation into mitochondria and chloroplasts, respectively
d. resetting biological clocks following rounds of intense protein synthesis

8. Protein sequences for targeting to mitochondria or chloroplasts are located at
a. the C-terminus of the precursor protein
b. amino acid position 173 in most mitochondrial and chloroplast proteins
c. the N-terminus of the precursor protein
d. At neither terminus.

9. Many peroxisomal matrix proteins are imported as
a. folded proteins
b. nascent chains in the process of completing their elongation
c. protein fragments that are spliced together within the peroxisome
d. unfolded proteins

10. Tom is an abbreviation for _____________________________________________________.

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