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Comparing Internal and External Antigen Presentation Pathways

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Describe the similarities and differences between the processing of intracellular vs extracellular antigens. Provide a table detailing these similarities and differences.

Compare and contrast the internal and external pathways of antigen processing and presentation to T cells. Make a table with 2 columns (one for each pathway) and make 5 distinct comparisons of the function and mechanisms of the 2 pathways.

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Solution Summary

This solution compares and contrasts the processing and presentation of intracellular antigens vs exogenous antigens. It also provides a table comparing several parameters in both pathways.

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** The table is attached as a .doc file and a pdf **

Internal antigens typically arise from viruses replicating inside infected cells, whereas external antigens are acquired from external sources such as bacteria or parasites. The internal pathway results in the presentation of a short peptide from the antigenic protein on the cell surface, inserted into the groove of an MHC class I molecule, that can then be recognized by CD8 T cells. Proteins in the cytosol are first degraded by a multi-protein complex known as the ...

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