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Generation of Diversity

Explain the purpose (and briefly the method) of generating a TCR transgenic mouse ? Why TCR transgenic mice are often made on a rag-/- background ?

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The purpose of generating a TCR transgenic mouse is to generate a mouse with a population of T-cells sharing a single TCR specificity. This is done by cloning the desired already-rearranged TCR genes (TCR is composed of 2 peptides encoded by 2 distinct genes). Mice expressing these cloned TCR ...

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