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    Protein Alpha Subunit Mutation

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    If the G protein alpha subunit has a mutation so that it can't hydrolyze GTP, what happens?. If the G-protein can only bind to GDP how would that effect the pathway?

    I believe if the alpha subunit has a mutation and cant hydrolyze GTP then the G-protein will be unable to inactivate itself. How will this be bad?

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    https://brainmass.com/biology/dna-chromosomes-and-genomes/protein-alpha-subunit-mutation-39222

    Solution Preview

    G proteins are heterotrimers. The alpha subunit acts as the signal transduction molecule when it binds GTP and dissociates from the trimer. After a short while, when GTP hydrolyzes to GDP and Pi, it reverts back to the inactive form (heterotrimeric) form. In other words, the active ...

    Solution Summary

    The expert examines protein alpha subunit mutations. The mutations which cannot hydrolyze GTP then the G-protein will be unable to inactivate itself is determined.

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