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Stimulation of a liver cell by glucagon

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How would you expect a nonhydrolyzable GTP analogue to affect signaling events that take place during the stimulation of a liver cell by glucagon? What would be the effect of the same analogue on signal transduction of an epithelial cell after exposure to epidermal growth factor (EGF)? How would this compare to the effects of the cholera toxin on these same cells?

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Detailed description of liver cell stimulation by glucagon and subsequent signaling cascades. Contains weblinks.

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There are a few things you need to know about the differences between the two signaling events you mentioned. The signaling events triggered by glucagon in the liver are achieved through G-protein signaling. Glucagon binds to a G (as in GTP) P (protein) C (coupled) R (receptor). The conformational change in the receptor leads to the exchange of GTP for GDP on a trimeric G-protein. The ...

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