The effect of base substitution on a protein function
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7. Which of the following changes (base substitutions and insertions are underlined and in bold) would have the most severe effect on the protein made from the mRNA? 5â??-AUG AGU AAA GGA UAA-3â??
a. AUG-AGU-AAG-GGA-UAA
b. AUG-AGU-AAA-GGA-UAG
c. AUG-GUA-AAG-GGU-UAA
d. AUG-AGU-AAA-GGA-GUA-A
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Solution Summary
An explanation for a role of a base substitution on protein function. The expert discuss how a single amino acid could affect protein function.
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The correct answer is c:
AUG-GUA-AAG-GGU-UAA
Explanation:
The changes in "c" would change the original peptide:
Met-Ser-Lys-Gly-STOP to
Met-Val-Lys-Gly-STOP.
Substituting serine with valine is likely to cause a drastic effect on protein function due to the ...
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