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    The effect of base substitution on a protein function

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    7. Which of the following changes (base substitutions and insertions are underlined and in bold) would have the most severe effect on the protein made from the mRNA? 5â??-AUG AGU AAA GGA UAA-3â??

    a. AUG-AGU-AAG-GGA-UAA
    b. AUG-AGU-AAA-GGA-UAG
    c. AUG-GUA-AAG-GGU-UAA
    d. AUG-AGU-AAA-GGA-GUA-A

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    https://brainmass.com/biology/dna-chromosomes-and-genomes/effect-base-substitution-protein-function-343697

    Solution Preview

    The correct answer is c:

    AUG-GUA-AAG-GGU-UAA

    Explanation:

    The changes in "c" would change the original peptide:
    Met-Ser-Lys-Gly-STOP to
    Met-Val-Lys-Gly-STOP.

    Substituting serine with valine is likely to cause a drastic effect on protein function due to the ...

    Solution Summary

    An explanation for a role of a base substitution on protein function. The expert discuss how a single amino acid could affect protein function.

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