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    Fructose bisphosphate aldolase

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    What is the evidence that fructose bisphosphate aldolase is a Class I Aldolase?

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    Response: Fructose bisphosphate aldolase (FBPA) belongs to the Class I Aldolase family because it catalyzes the cleavage of fructose 1,6-bisphosphate (FBP) through an intermediate Schiff base between the conserved and invariant active site Lysine (K) and the C2 carbonyl group on FBP. Once the Schiff base is formed, a glutamate residue acts as a proton donor to cleave the C3-C4 bond forming the two products, dihydroxyacetone phosphate (DHAP) and glyceraldehyde C-C bond cleavage. If you want, you can go to http://www.chem.uwec.edu/Webpapers2005/lawrenmj/pages/page_1.html to see a short summary of the basic mechanism of this enzyme.

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    Solution Summary

    This solution describes fructose bisphosphate aldolase and provides evidence that it is a Class I Aldolase.