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Conditioned Learning

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1) How can you demonstrate spontaneous recovery in a laboratory with rats?
2) Make up an example of conditioned inhibition and make sure to label all the parts ( CS+, CS-, CR, US, UR).
3) Develop an example of higher-order conditioning pointing out the US, UR, CS, CR.

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RESPONSE:

Interesting questions! Let's take a closer look, through a brief paragraph for each. However, because it is important to understand the main concepts of conditioning, I provided extra reading and information for each question in case you need further clarification.

1. How can you demonstrate spontaneous recovery in a laboratory with rats?

Many studies that demonstrate spontaneous recovery in a laboratory with rats use a drug that creates an effect, such as allergic reaction (as seen the abstract in the first example below). The rat then demonstrates a spontaneous recovery when the allergic reaction disappears, and we conclude that the rat recovered spontaneously from the effects of the drug.

Extra Reading and Understanding:

Illustrative Example: Spontaneous recovery of rats from experimental allergic encephalomyelitis is dependent on regulation of the immune system by endogenous adrenal corticosteroids. (MacPhee IA, Antoni FA, Mason DW).

Lewis rats with experimental allergic encephalomyelitis (EAE), induced either by the subcutaneous injection of guinea pig myelin basic protein (MBP) or by the adoptive transfer of MBP-primed spleen cells, suffer from a single episode of paralysis from which they recover spontaneously. Animals developing EAE were found to have greatly elevated levels of corticosterone in the blood. This endogenous increase in steroid production was accompanied by lymphopenia and depressed delayed-type hypersensitivity responses to OVA, indicating that rats with EAE are ...

Solution Summary

This solution discusses how a person can demonstrate spontaneous recovery in a laboratory with rats. An example is provided of conditioned inhibition and make sure to label all the parts ( CS+, CS-, CR, US, UR), as well as an example of higher-order conditioning pointing out the US, UR, CS, CR.

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