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margin of safety for fluoride

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Is there a substantial margin of safety? What is the numeric value for the margin of safety? Show your calculations and explain your reasoning.

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Fluoride usage has been debated repeated due to its various positive contributions to dental health, however there has also been concerns with the safety of increased fluoride being incorporated into daily items, such as public water sources. According to the US Department of Health and Human Services, the level of adequate intake for fluoride which produces a desired dental health without causing harmful effects to the body is 0.05 mg/kg/day (milligram per kilogram of body weight per day)(US, 1991). However, author Kenji Akiniwa notes that "the acute toxic dose of fluoride has been believed to be 2 to 5 mg or 8 mg/kg of body weight. However, ...

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Question response includes: Is there a substantial margin of safety? What is the numeric value for the margin of safety? Show your calculations and explain your reasoning. The explanation is given in 429 words with one reference.

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