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    DNA Coiling and Topoisomerase

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    Can someone please explain this problem to me? I don't get how to sketch the writhe accurately with a topoisomerase I to alter the structure.

    Please draw a circular DNA molecule that contains 3 negative supercoils. In this DNA molecule, make L = 250 and T = 253. Don't draw the details here i.e., all 250 of the strand passages around each other. Focus on sketching the writhe accurately. Now imagine adding a type I topoisomerase. Draw the three most likely products, write the values for L, T and W for each molecule.

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    https://brainmass.com/chemistry/stereochemistry-bonding-and-formation/dna-coiling-topoisomerase-523589

    Solution Preview

    ** Please see the attached file for the illustrated solution **

    Basically, topoisomerase I relaxes negative supercoiling. ...

    Solution Summary

    The L, T and W values for topioisomerase is calculated based on its structure. An illustration of the structure is provided.

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