Explore BrainMass

Explore BrainMass

    DNA Coiling and Topoisomerase

    This content was COPIED from BrainMass.com - View the original, and get the already-completed solution here!

    Can someone please explain this problem to me? I don't get how to sketch the writhe accurately with a topoisomerase I to alter the structure.

    Please draw a circular DNA molecule that contains 3 negative supercoils. In this DNA molecule, make L = 250 and T = 253. Don't draw the details here i.e., all 250 of the strand passages around each other. Focus on sketching the writhe accurately. Now imagine adding a type I topoisomerase. Draw the three most likely products, write the values for L, T and W for each molecule.

    © BrainMass Inc. brainmass.com October 10, 2019, 5:58 am ad1c9bdddf

    Solution Preview

    ** Please see the attached file for the illustrated solution **

    Basically, topoisomerase I relaxes negative supercoiling. ...

    Solution Summary

    The L, T and W values for topioisomerase is calculated based on its structure. An illustration of the structure is provided.