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Dose-response on an organism

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What are the advantages and disadvantages of animal studies and epidemiological studies for establishing dose-response relationships?

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Solution Summary

The Dose-response relationship describes the change in effect on an organism caused by differing levels of exposure (or doses) to a stressor (usually a chemical). This may apply to individual or to populations.

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Principles of Toxicology

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3) Definition of toxicology?

4) What do you understand by the term dose? How can you estimate it?

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8) What is the impact on this relationship if there is more than one effect of a chemical?

9) What do you understand by the term 'threshold of effect'?

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12) What do you understand by the term biological half time?

13) What is the significance, when setting threshold for adverse effects, of the fact that, broadly speaking, solid particulates have much longer biological half times than gases and vapours?

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15) Outline some general mechanisms of toxicity?

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17) Discuss the limitations of animal testing methods in the evaluation of human toxic potential of chemicals?

18) Outline a strategy for testing for carcinogenicity of industrial chemicals

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