1.) What virulence factors are important in establishing a Salmonella infection?
Note: Please make responses at least 3 paragraphs and cite references.
Samonella is the causative agent of a well known bacterial disease called Salmonellosis. While age and health status are important factors during disease contraction and infection, more often than not, people particularly very young children, patients with organ transplant and those affected with HIV/AIDS suffer a lot after getting infected via contaminated food especially spoiled chicken or eggs (Heather Bair-Brake, n.d.; Owens, 2010). The disease is characterized by clinical symptoms ranging from a "gastroenteritis, enteric fever, bacteremia, focal infections, to a convalescent lifetime carrier state" (Owens, 2010).
Pathophysiology and Virulence Factors
The virulence factors that contribute to the establishment of salmonellosis cannot be fully understand without first understanding the basic concepts of how salmonella causes disease. Following ingestion of contaminated food, the bacteria immediately colonize and translocate across the epithelial layer of the intestine via either enterocyte or M cell invasion or through dendritic cells along the intestinal surface (Owens, 2010). This colonization invariably result to proinflammatory response with the activation of cytokines, chemokines, neutrophils, macrophages, dendritic cells, and T and B cells (Owens, 2010). The bacteria then successfully penetrate the epithelial wall ...
Samonella is thoroughly explained using research to validate.