1. Describe the function of corticotrophin-releasing hormone (CRH) from the hypothalamus.
2. Explain why CRH levels would be low when ACTH levels are high. There is a negative feedback loop that inhibits CRH production when ACTH levels are high.
3. Steroid hormones fall into the lipid soluble category. What is the important of cholesterol to all steroid molecules? All steroid hormones are derived from cholesterol molecules.
Hope this helps you.
The corticotrophin-releasing hormone (CRH) is one of the hypothalamic releasing hormones that maintain homeostasis in the body by a negative feedback mechanism. The hypothalamic secretion of CRH stimulates the anterior pituitary to produce adrenocorticotropic hormone (ACTH) in the corticotrophs (constituting 15-20% of the cells of the anterior pituitary) by a proteolytic processing of of Prepro-opiomelanocortin a.k.a POMC (Khoo & Grossmam, 2011). ACTH main function is to regulate adrenal cortex and synthesis of adrenocorticosteroids (Owen,n.d.; Pralong, n.d.).
A) The negative feedback mechanism of CRH can be explained as follows:
Hypothalamus -> produces CRH -> stimulates the anterior pituitary -> increases production of ACTH -> stimulates adrenal cortex ->increases cortisol (a glucocorticoid).....(then).... an increase in cortisol->tells hypothalamus to stop CRH and the pituitary to stop ACTH productions.
B) Another feedback mechanism is that of ADH.
ACTH release is stimulated (in conjunction with CRH) by vasopressin or antidiuretic hormone (ADH) that is released by the posterior pituitary and reaches anterior pituitary via inferior ...
The expert describes the functions of corticotrophin-releasing hormone from the hypothalamus. Why CRH levels would be low when ACTH levels are high are determined.
Senses and Endocrine System
The endocrine system plays an important role in our ability to handle stress. Hormone release associated with the stress response can help us to survive and handle crisis situations. However, chronic stress can result in unregulated release of stress hormones that can have negative effects on the brain and our immune systems. prepare a 2-3 page paper in which you:
Describe the difference between acute and chronic stressors
Describe the stress response and the effects of cortisol release on the human body. (With which division of the nervous system is the stress response associated?)
Discuss and label the components of HPA axis and its feedback mechanisms.
Discuss the pathologies associated with dysregulation of cortisol, focusing on the brain and the immune system.
Engage in independent research to learn about diseases of the endocrine system. You may want to begin your search in the book, Human Anatomy and Physiology: Cortisol: Physiology, Regulation, and Health Implications, on your ebrary bookshelf.
Select "Ebrary"from Trident's Online Library website: https://coursenet.trident.edu/onlinelibrary_main.php
You will find the readings on the Anatomy and Physiology I Ebrary bookshelf which can be accessed via this link as well:
Ebrary bookshelf (folder): http://site.ebrary.com/lib/tourou/viewFolder.action?sharedKey=DKSFJONSEEDWBRRYAZOBDBDMKFLLPYHR&userName=trmurray
Bobick, J and Balaban, N. "Sensory System," and "Endocrine System" Handy Anatomy Answer Book. Visible Ink Press. MI, USA. 2008. eISBN: 9781578592326
Brooks, Arthur. "Endocrine System." Systems of Our Body. Global Media. Delhi, India. 2007. eISBN: 9788189940829View Full Posting Details