The Molecular Version of Koch's Postulates
For the table attached pick one of the gene products, and write a hypothetical Koch's postulates molecur version to identify the gene product as a virulence factor in the infection model, which is also listed on the table.
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For this exercise I picked H. influenza's penicillin binding protein 7 (pbp7) which causes bacteremia upon intraperitoneal injection of the organism into an infant rat model.
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Solution Summary
In 1890, German baceteriologist Robert Koch presented a set of criteria for judging whether a particular organism was responsible for causing disease symptoms. Fact is we still use those postulates today and have even refined them to describe the molecular genetics involved in virulence.
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