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    The Molecular Version of Koch's Postulates

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    For the table attached pick one of the gene products, and write a hypothetical Koch's postulates molecur version to identify the gene product as a virulence factor in the infection model, which is also listed on the table.

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    https://brainmass.com/biology/human-biology/molecular-version-kochs-postulates-148383

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    Hello

    For this exercise I picked H. influenza's penicillin binding protein 7 (pbp7) which causes bacteremia upon intraperitoneal injection of the organism into an infant rat model.
    Our molecular Koch's postulates would then look as follows:
    1.pbp7 should be associated with pathogenic H. influenza and be absent from nonpathogenic strains.
    2.Mutation of the pbp7 should lead to a measurable loss in virulence in comparison to the unmutated H. influenza when introduced into the infant rat model.
    3.Reintroducing a functional copy of pbp7 into the mutant strain should restore virulence in the infant rat model.

    Extra information about Molecular Koch's postulates:
    Falkow S (1988). "Molecular Koch's postulates applied to microbial pathogenicity." Rev Infect Dis 10(suppl 2):S274-S276.

    Cheers,

    Will Spencer

    This content was COPIED from BrainMass.com - View the original, and get the already-completed solution here!

    © BrainMass Inc. brainmass.com December 24, 2021, 6:54 pm ad1c9bdddf>
    https://brainmass.com/biology/human-biology/molecular-version-kochs-postulates-148383

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