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Germ Theory of Disease

In Module 1 you selected an example of resident microbiota.

In this Module, selected another resident microbe from "Chapter 2: Host-Microbe Interactions" in A Concise Manual of Pathogenic Microbiology, that can cause disease in humans.

1. Discuss the germ theory of disease.

2. Describe the human diseases which are produced by the pathogenic microorganism selected. Does it exist in a non-pathogenic state as well? Under what health condition can the disease be produced?

Include in your discussion:

The differences between eukaryotic and prokaroytic cells.
Three phenotypic systems used to classify microbes.
Use the classification system discussed to classify each microbe selected in Modules 1 and 2.
Please upload your M2 SLP when it is completed.

Recommended format:

Module 2 - Structure and Evolution of Microbes

Introduction: Prokaryotes, Eukaryotes and the three pheontypic systems used to classify microbes
Organism 1, classification
Organism 2, classification
Comparisons and contrasts, pathogenic vs non-pathogenic states, opportunistic or symbiotic?
Note: A "PR" grade will be assigned to SLP Module assignments where critical thinking is not an important factor. The "PR" grade means "Progress"; however, in practical terms it means that the student's work is satisfactory.

Your assignment is due by the Monday following the end of this Module. Please upload your case assignment.

Session Long Project Assignment Expectations

Length: Each module SLP should be approximately a minimum of 2-4 pages or approximately 500 to 650 words.

References: At least two references should be included from academic sources (e.g. peer-reviewed journal articles). Required readings are included. Quoted material should not exceed 10% of the total paper (since the focus of these assignments is critical thinking). Use your own words and build on the ideas of others. When material is copied verbatim from external sources, it MUST be enclosed in quotes. The references should be cited within the text and also listed at the end of the assignment in the References section (preferably in APA format).

Organization: Subheadings should be used to organize your paper according to question

Format: APA format is recommended (but not required) for this assignment. See Syllabus page for more information on APA format.

Grammar and Spelling: While no points are deducted, assignments are expected to adhere to standards guidelines of grammar, spelling, punctuation, and sentence syntax. Points may be deducted if grammar and spelling impact clarity.

The following items will be assessed in particular:

Relevance (e.g. all content is connected to the question)
Precision (e.g. specific question is addressed. Statements, facts, and statistics are specific and accurate).
Depth of discussion (e.g. present and integrate points that lead to deeper issues)
Breadth (e.g. multiple perspectives and references, multiple issues/factors considered)
Evidence (e.g. points are well-supported with facts, statistics and references)
Logic (e.g. presented discussion makes sense, conclusions are logically supported by premises, statements, or factual information)
Clarity (e.g. writing is concise, understandable, and contains sufficient detail or examples)
Objectivity (e.g. avoid use of first person and subjective bias)

Solution Preview

Module 2 SLP
In Module 1 you selected an example of resident microbiota.
In this Module, selected another resident microbe from "Chapter 2: Host-Microbe Interactions" in A Concise Manual of Pathogenic Microbiology, that can cause disease in humans.

1. Discuss the germ theory of disease.

Germ theory of disease states that "specific microscopic organisms are the cause of specific diseases. In other words, it states that diseases are caused by the presence and actions of specific microorganisms within the body.
In 1546-1553, Fracastorius developed the theory of contagion in which disease infection can be caused by minute bodies ("germs") capable of self-replication, transmitted from infector to infected.
In 1670s, Leeuwenhoek improved the microscope and was the first to observe bacteria. However the germ theory of disease came into development when in 1834, Agostino Bassi was the first to show that a microorganism could cause disease in the case of a fungal disease of silkworms. Louis Pasteur ( 1865) had demonstrated that spoilage of wine was due to abnormal microorganisms. He also showed another disease of silkworms that can be halted by identifying diseased worms that can be removed and destroyed.
Robert Koch ( 1876) raced to find the cause of anthrax that are disease of sheep and cattle. He first demonstrated that the bacillary agent is pathogenic. He developed the Koch's postulates that are criteria by which a bacterium is said to cause a disease. Using microscopic examination, he found that the blood of all animals contain anthrax.
Chamberland (1884) showed that tobacco mosaic disease was caused by "filterable" agent called virus.
Edward Jenner (1798) inoculated susceptible person with pus from cowpox lesion and conferred resistance to Small Pox.

2. Describe the human diseases which are produced by the pathogenic microorganism selected.
Include in your discussion:
The differences between eukaryotic and prokaroytic cells.
Three phenotypic systems used to classify microbes.

The pathogenic microorganism selected is the bacteria Mycobacterium tuberculosis that caused the disease Tuberculosis. ...

Solution Summary

Germ theory of disease states that "specific microscopic organisms are the cause of specific diseases. In other words, it states that diseases are caused by the presence and actions of specific microorganisms within the body.

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